The Metabolics Laboratory at SickKids Hospital
The proceeds from the 2006 Mito March are being
used to fund a scientific study currently being conducted in the Metabolics Lab at SickKids Hospital. This new project involves
costs not easily financed by traditional funding sources. Scientists are analyzing the DNA of sibling pairs from different
families with Complex One Deficiency- a rare mitochondrial disease.
By employing methods very similar to the ones used
by the SickKids researchers who found the gene responsible for Cystic Fibrosis, metabolic scientists are mapping out and identifying
mitochondrial genes that are common to both siblings. These common genes are in turn, linked to the genes shared by siblings
from other families with the intention of narrowing down the location of defect and eventually pinpointing the specific gene
responsible for Complex One Deficiency.
It is hoped that this study will provide a window
into what the real genetic causes might be therefore, having profound implications for diagnosis, prenatal diagnosis and treatment
of those families affected by this disease.
Mito March supporters share pride in knowing that
their efforts are bringing a much welcomed hope to those who suffer from the fatal effects of this disease.
